Publications

Books/textbooks for the medical or scientific community [6 Books Published]:

1. Bhanu P. Jena (2020). Cellular Nanomachines Natures Engineered Marvels. Springer Nature p1-109, ISBN: 9783030444952 [Cover: Schematic representation of the Porosome Complex].



2. Bhanu P. Jena, Douglas Taatjes (2014). NanoCellBiology: Multimodal Imaging in Biology & Medicine Pan Sanford Publishing Pte. Ltd. p1-400, ISBN: 9789814411790 [Cover: Neuronal Porosome Complex].



3. Bhanu P. Jena  (2012). NanoCellBiology of Secretion: Imaging its Cellular and Molecular Underpinnings. Springer Briefs in Biological Imaging 1:1-70.



4. Bhanu P. Jena (2008). Methods in nano cell biology. Methods in Cell Biology, Academic Press 90:1-505. [Cover: Porosome Complex].



5. Bhanu P. Jena,  J. K. Heinrich Horber (2006). Force microscopy: application in biology and medicine. Wiley & Sons, Inc. 1-300. [Cover: Porosome Complex].



6. Bhanu P. Jena, J. K. Heinrich Horber (2002). Atomic force microscopy in cell biology. Methods in Cell Biology, Academic Press 68:1-409. [Cover: Porosome Complex].




Papers
 
1. Exosomes in Epilepsy of Tuberous Sclerosis Complex: Carriers of Pro-Inflammatory MicroRNAs.
Cukovic D, Bagla S, Ukasik D, Stemmer PM, Jena BP, Naik AR, Sood S, Asano E, Luat A, Chugani DC, Dombkowski AA.
Non-Coding Rna. 7. PMID 34287356 DOI: 10.3390/ncrna7030040.

2. Regulation of Hepatic Circadian Metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα Transcriptional Program.
Kim H, Wei J, Song Z, Mottillo E, Samavati L, Zhang R, Li L, Chen X, Jena BP, Lin JD, Fang D, Zhang K.
Molecular Metabolism. 101192. PMID 33592335DOI: 10.1016/j.molmet.2021.101192

3. Skeletal muscle remodeling in immobilized patients: Determined using a parameter estimation histomorphometric approach.
Gatti DL, Larsson L, Arslanturk S, Jena BP.
bioRxiv.2020.06.17.157438; doi: https://doi.org/10.1101/2020.06.17.157438.

4. Cystic fibrosis transmembrane conductance regulator (CFTR) inhibition results in mucus accumulation in human airway epithelia Calu-3 cells: Experimental and machine learning studies.
Laethem BS, Lewis KT, Ramos R, Hou X, Sun F, Taatjes DJ, Jena BP, Arslanturk, S.
bioRxiv. 2020.06.17.157438; doi: https://doi.org/10.1101/2020.06.17.157438.

5. Nanoscale imaging using differential expansion microscopy.
Pernal, S.P., Liyanaarachchi, A., Gatti, D.L., Formosa, B., Pulvender, R., Kuhn, E.R., Ramos, R., Naik, A.R., George, K., Arslanturk, S., Taatjes, D.J., Jena, B.P. 
Histochem Cell Biol.(2020) doi:https://doi.org/10.1007/s00418-020-01869-7

6. Res-CR-Net, a residual network with a novel architecture optimized for the semantic segmentation of microscopy images.
Abdallah, H., Liyanaarachchi, A., Saigh, M., Silvers, S., Arslanturk, S., Taatjes, D.J., Larsson, L., Jena, B.P., Gatti,D.L.
arXiv (2020); doi: https://arxiv.org/abs/2004.08246v1

7. vH-ATPase-induced intracellular acidification is critical to glucose-stimulated insulin secretion in beta cells.
Naik AR, Formosa BJ, Pulvender RG, Liyanaarachchi AG, Jena BP. 
Histochemistry and Cell Biology. (2019) PMID 31901974 DOI: 10.1007/s00418-019-01841-0

8. Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model.
Cacciani N, Salah H, Li M, Akkad H, Backeus A, Hedstrom Y, Jena BP, Bergquist J, Larsson L.
Acta Physiologica (Oxford, England) (2019) . e13425. PMID 31799784 DOI: 10.1111/apha.13425

9. Self-Assembly and Biogenesis of Cellular Membrane is Dictated by Membrane Stretch and Composition.
Naik AR, Kuhn ER, Lewis KT, Kokotovich KM, Maddipati KR, Chen X, Hörber JHK, Taatjes DJ, Potoff J, Jena BP. 
The Journal of Physical Chemistry. (2019) B. 123(32): 6997-7005. PMID 31322890 DOI: 10.1021/acs.jpcb.9b04769
(A comprehensive understanding of the biogenesis of additional membrane to pre-existing cellular membrane determined by the study)

10. Exosome- enriched fractions from multiple sclerosis B cells induce oligodendrocyte death.
Benjamins JA, Nedelkoska L, Touil H, Stemmer, Carruthers NJ, Jena BP, Naik AR, Bar-Or A, Lisak RP.
Neurology(R) Neuroimmunology & Neuroinflammation.(2019) 6: e550. PMID 31044144 DOI: 10.1212/NXI.0000000000000550

11. Human skeletal muscle cells on engineered 3D platform express key growth and developmental proteins.
Naik AR, Pernal S, Lewis KT, Wu Y, Wu H, Carruthers NJ, Stemmer PM, Jena BP.
 ACS Biomaterials Science & Engineering (2019) DOI: 10.1021/acsbiomaterials.8b01338.

12. Differential expansion microscopy.
Pernal, S.P., Liyanaarachchi, A., Gatti, D.L., Formosa, B., Pulvender, R., Kuhn, E.R., Ramos, R., Naik, A.R., George, K., Arslanturk, S., Taatjes, D.J., Jena BP. 
bioRxiv (2019) 699579; doi: https://doi.org/10.1101/699579
(Demonstrated that in expansion microscopy (ExM), anisotrophic expansion is observed between tissues, between cells, between cellular organelles, and even within organelles themselves, hence called differential expansion microscopy (DiExM))

13. Deep learning strategies for differential expansion microscopy.
Gatti, D.L., Arslanturk, S., Lal, S., Jena BP. 
bioRxiv (2019) 743682; doi: https://doi.org/10.1101/74368

14. Nanothermometry Reveals Calcium-Induced Remodeling of Myosin.
Kuhn ER, Naik AR, Lewis BE, Kokotovich KM, Li M, Stemmler TM, Larsson L, Jena BP.
ACS Nano Letters October 22, 2018, DOI: 10.1021/acs.nanolett.8b02989
(Enthalpy changes in the motor protein myosin, and the consequent loss in the alpha helical content of the protein demonstrated following calcium binding)

15. Human Skeletal Muscle Cell Atlas: Unraveling Cellular Secrets Utilizing ‘Muscle-on-a-Chip’, Differential Expansion Microscopy, Mass Spectrometry, Nanothermometry and Machine Learning.
Jena BP, Gatti DL, Arslanturk S, Pernal S, Taatjes DJ.
Micron https://doi.org/10.1016/j.micron.2018.11.002

16. Valproate inhibits glucose-stimulated insulin secretion in beta cells.
Yedulla NR, Naik AR, Kokotovich KM, Yu W, Greenberg ML, Jena BP.
Histochem Cell Biol. 2018 Aug 25. doi: 10.1007/s00418-018-1713-6. PMID: 30145684
(First demonstration of the reduction of glucose-stimulated insulin secretion in beta cells following exposure to Valproate, an FDA approved drug that has been used clinically for decades, in treating migraines, bipolar disorder, and epileptic seizures.)

17. Secretion induces cell pH dynamics impacting assembly-disassembly of the fusion protein complex: A combined fluorescence and atomic force microscopy study.
Lewis KT, Naik AR, Laha SS, Wang S, Mao G, Kuhn E, Jena BP. 
Semin Cell Dev Biol. 2018 Jan;73:57-63. doi: 10.1016/j.semcdb.2017.08.003. Epub 2017 Aug 3. PMID: 28779980
(Secretion induces pH dynamics of cells impacting assembly-disassembly of the membrane-associated t-SNAREs and v-SNARE complex complex)

18. Molecular architecture of mouse and human pancreatic zymogen granules: protein components and their copy numbers.
Lee JS, Caruso JA, Hubbs G, Schnepp P, Woods J, Fang J, Li C, Zhang K, Stemmer PM, Jena BP, Chen X.
Biophys Rep. 2018;4(2):94-103. doi: 10.1007/s41048-018-0055-1. Epub 2018 Apr 26. PMID: 29756009

19. Porosome: Supramolecular Structures at the Synaptosome Membrane Involved in Vesicle Docking, Fusion, and Neurotransmitter Release.
Jena BP.
Synaptosome Methods and Applications Springer Nature. Editor: Murphy K.; Series Editor: Walz W. 2018 Humana Press ISSN: 0893-2336.

20. Nano thermometry measure of muscle efficiency.
Laha SS, Naik AR, Kuhn ER, Alvarez M, Sujkowsky A, Wessells RJ, Jena BP.
ACS Nano Letters 2017 Jan 23. DOI: 10.1021/acs.nanolett.6b05092
Patent: US 62/498,015.
(Establishes a novel approach to determine muscle efficiency, with promise for early diagnosis and treatment of various metabolic disorders including cancer)

21. Unique lipid chemistry of synaptic vesicle and synaptosome membrane revealed using mass spectrometry.
Lewis KT, Maddipati KR, Naik AR, Jena BP.
ACS Chemical Neuroscience. 2017 DOI: 10.1021/acschemneuro.7b00030. PMID: 28244738.
(Tight regulation of nerve cells in compartmentalization of membrane lipids at the nerve terminal is demonstrated)

22. Human Platelet Vesicles Exhibit Distinct Size and Proteome.
Jena BP, Stemmer PM, Wang S, Mao G, Lewis KT, Walz DA.
ACS J Proteome Res. 2017 Jun 9. doi: 10.1021/acs.jproteome.7b00309. [Epub ahead of print] PMID:28587468

23. Secretion induces cell pH dynamics impacting assembly-disassembly of the fusion protein complex: a combined fluorescence and atomic force microscopy study.
Lewis KT, Naik AR, Laha SS, Wang S, Mao G, Kuhn E, Jena BP.
Seminars in Cell and Development Biology 2017 9.http://www.sciencedirect.com/science/article/pii/S1084952117300149

24. Functionalized nanoparticles enable tracking the rapid entry and release of doxorubicin in human pancreatic cancer cells.
Arachchige MP, Laha SS, Naik AR, Lewis KT, Naik R, Jena BP.
Micron. 2017 Jan;92:25-31. doi: 10.1016/j.micron.2016.10.005. PMID: 27846432

25. Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells.
Naik AR, Kulkarni SP, Lewis KT, Taatjes DJ, Jena BP.
Endocrinology. 2016 Jan;157(1):54-60. doi: 10.1210/en.2015-1653. PMID: 26523491
(Porosome functionally reconstituted into live cells for the first time)

26. The neuronal porosome complex in health and disease.
Naik AR, Lewis KT, Jena BP.
Exp Biol Med (Maywood). 2016 Jan;241(2):115-30. doi: 10.1177/1535370215598400. PMID: 26264442

27. Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.
Najy AJ, Dyson G, Jena BP, Lin CY, Kim HR.
Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C293-304. doi: 10.1152/ajpcell.00043.2015. PMID: 26157007

28. Nanometric features of myosin filaments extracted from a single muscle fiber to uncover the mechanisms underlying organized motility.
Li M, Deguchi T, Näreoja T, Jena BP, Hänninen P, Larsson L.
Arch Biochem Biophys. 2015 Oct 1;583:1-8. doi: 10.1016/j.abb.2015.06.010. PMID: 26116379

29. COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.
Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X.
Mol Endocrinol. 2015 Aug;29(8):1156-69. doi: 10.1210/me.2015-1012. PMID: 26083833

30. 'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion.
Jena BP.
J Cell Mol Med. 2015 Jul;19(7):1427-40. doi: 10.1111/jcmm.12598. PMID: 26033351

31. Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function.
Rajagopal A, Kulkarni S, Lewis KT, Chen X, Maarouf A, Kelly CV, Taatjes DJ, Jena BP.
J Proteomics. 2015 Jan 30;114:83-92. doi: 10.1016/j.jprot.2014.11.010. PMID: 25464371

32. Neuronal Porosome-The Secretory Portal at the Nerve Terminal: It's Structure-Function, Composition, and Reconstitution.
Jena BP. 
J Mol Struct. 2014 Sep 5;1073:187-195. PMID: 26412873

33. Neuronal porosome lipidome.
Lewis KT, Maddipati KR, Taatjes DJ, Jena BP.
J Cell Mol Med. 2014 Oct;18(10):1927-37. doi: 10.1111/jcmm.12383. PMID: 25224862
(Some core lipids constituting the neuronal porosome complex in the rat brain was determined in the study)

34. Porosome in Cystic Fibrosis.
Jena BP.
Discoveries (Craiova). 2014 Jul-Sep;2(3). pii: e24. PMID: 26413568

35. Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR).
Hou X, Lewis KT, Wu Q, Wang S, Chen X, Flack A, Mao G, Taatjes DJ, Sun F, Jena BP. 
J Proteomics. 2014 Jan 16;96:82-91. doi: 10.1016/j.jprot.2013.10.041. PMID: 24220302

36. X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release.
Kovari LC, Brunzelle JS, Lewis KT, Cho WJ, Lee JS, Taatjes DJ, Jena BP.
Micron. 2014 Jan;56:37-43. doi: 10.1016/j.micron.2013.10.002. PMID: 24176623
(Native neuronal porosome structure determined using solution X-ray. The X-ray solution structure of synaptic vesicles docked at porosomes present at the presynaptic membrane of isolated rat brain synaptosomes, was determined for the first time in the study)

37. CXCR2 macromolecular complex in pancreatic cancer: a potential therapeutic target in tumor growth.
Wang S, Wu Y, Hou Y, Guan X, Castelvetere MP, Oblak JJ, Banerjee S, Filtz TM, Sarkar FH, Chen X, Jena BP, Li C.
Transl Oncol. 2013 Apr;6(2):216-25. Erratum in: Transl Oncol. 2013 Dec;6(6):erratum. PMID: 23544174

38. Atomic force microscopy: High resolution dynamic imaging of cellular and molecular structure in health and disease.
Taatjes DJ, Quinn AS, Rand JH, Jena BP.
J Cell Physiol. 2013 Oct;228(10):1949-55. doi: 10.1002/jcp.24363. PMID: 23526453

39. Aquaporin-assisted and ER-mediated mitochondrial fission: a hypothesis.
Lee JS, Hou X, Bishop N, Wang S, Flack A, Cho WJ, Chen X, Mao G, Taatjes DJ, Sun F, Zhang K, Jena BP.
Micron. 2013 Apr;47:50-8. doi: 10.1016/j.micron.2013.01.005. PMID: 23416165

40. Porosome: the secretory NanoMachine in cells.
Jena BP.
Methods Mol Biol. 2013;931:345-65. doi: 10.1007/978-1-62703-056-4_17. PMID: 23027011

41. Porosome: the secretory portal.
Jena BP.
Exp Biol Med (Maywood). 2012 Jul;237(7):748-57. doi: 10.1258/ebm.2012.012110. PMID: 22859740

42. Neuronal porosome proteome: Molecular dynamics and architecture.
Lee JS, Jeremic A, Shin L, Cho WJ, Chen X, Jena BP.
J Proteomics. 2012 Jul 16;75(13):3952-62. doi: 10.1016/j.jprot.2012.05.017. PMID: 22659300 Free PMC Article
(Core proteins constituting the neuronal porosome complex in the rat brain was determined in the study)

43. 3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex.
Wang S, Lee JS, Bishop N, Jeremic A, Cho WJ, Chen X, Mao G, Taatjes DJ, Jena BP.
Histochem Cell Biol. 2012 Jun;137(6):703-18. doi: 10.1007/s00418-012-0948-x. PMID: 22527693

44. Lysophosphatidylcholine inhibits membrane-associated SNARE complex disassembly.
Shin L, Wang S, Lee JS, Flack A, Mao G, Jena BP.
J Cell Mol Med. 2012 Aug;16(8):1701-8. doi: 10.1111/j.1582-4934.2011.01433.x. PMID: 21883893

45. Water channels in platelet volume regulation.
Lee JS, Agrawal S, von Turkovich M, Taatjes DJ, Walz DA, Jena BP.
J Cell Mol Med. 2012 Apr;16(4):945-9. doi: 10.1111/j.1582-4934.2011.01362.x. PMID: 21692982

46. Role of SNAREs in membrane fusion.
Jena BP.
Adv Exp Med Biol. 2011;713:13-32. doi: 10.1007/978-94-007-0763-4_3. PMID: 21432012

47. Conformation states of the neuronal porosome complex.
Cho WJ, Lee JS, Jena BP.
Cell Biol Int. 2010 Nov;34(11):1129-32. doi: 10.1042/CBI20100510. PMID: 20939833

48. Ca(2+) bridging of apposed phospholipid bilayers.
Issa ZK, Manke CW, Jena BP, Potoff JJ.
J Phys Chem B. 2010 Oct 21;114(41):13249-54. doi: 10.1021/jp105781z. PMID: 20836527

49. Membrane-directed molecular assembly of the neuronal SNARE complex.
Cho WJ, Lee JS, Zhang L, Ren G, Shin L, Manke CW, Potoff J, Kotaria N, Zhvania MG, Jena BP.
J Cell Mol Med. 2011 Jan;15(1):31-7. doi: 10.1111/j.1582-4934.2010.01152.x. PMID: 20716122

50. Involvement of cholesterol in synaptic vesicle swelling.
Lee JS, Cho WJ, Shin L, Jena BP.
Exp Biol Med (Maywood). 2010 Apr;235(4):470-7. doi: 10.1258/ebm.2010.009259. PMID: 20407079

51. Membrane lipids influence protein complex assembly-disassembly.
Shin L, Cho WJ, Cook JD, Stemmler TL, Jena BP.
J Am Chem Soc. 2010 Apr 28;132(16):5596-7. doi: 10.1021/ja101574d. PMID: 20373736

52. Involvement of β-adrenergic receptor in synaptic vesicle swelling and implication in neurotransmitter release.
Chen ZH, Lee JS, Shin L, Cho WJ, Jena BP.
J Cell Mol Med. 2011 Mar;15(3):572-6. doi: 10.1111/j.1582-4934.2010.01026.x. PMID: 20132410

53. Secretory vesicles transiently dock and fuse at the porosome to discharge contents during cell secretion.
Jena BP.
Cell Biol Int. 2009 Dec 16;34(1):3-12. doi: 10.1042/CBI2009016. PMID: 20017733

54. Functional organization of the porosome complex and associated structures facilitating cellular secretion.
Jena BP.
Physiology (Bethesda). 2009 Dec;24:367-76. doi: 10.1152/physiol.00021.2009. PMID: 19996367

55. Structure of membrane-associated neuronal SNARE complex: implication in neurotransmitter release.
Cho WJ, Shin L, Ren G, Jena BP.
J Cell Mol Med. 2009 Oct;13(10):4161-5. doi: 10.1111/j.1582-4934.2009.00895.x. PMID: 19737333

56. Involvement of vH(+)-ATPase in synaptic vesicle swelling.
Shin L, Basi N, Jeremic A, Lee JS, Cho WJ, Chen Z, Abu-Hamdah R, Oupicky D, Jena BP.
J Neurosci Res. 2010 Jan;88(1):95-101. doi: 10.1002/jnr.22180. PMID: 19610106

57. Membrane fusion: role of SNAREs and calcium.
Jena BP.
Protein Pept Lett. 2009;16(7):712-7. Review. PMID: 19601899

58. Atomic force microscopy: Unraveling the fundamental principles governing secretion and membrane fusion in cells.
Jena BP.
Ultramicroscopy. 2009 Jul;109(8):1094-104. doi: 10.1016/j.ultramic.2009.03.043. PMID: 19443122

59. Circular dichroism (CD) spectroscopy of the assembly and disassembly of SNAREs: The proteins involved in membrane fusion in cells.
Cook JD, Cho WJ, Stemmler TL, Jena BP.
Chem Phys Lett. 2008 Sep 1;462(1-3):6-9. PMID: 19412345

60. Porosome: the secretory portal in cells.
Jena BP.
Biochemistry. 2009 May 19;48(19):4009-18. doi: 10.1021/bi9002698. Review. Erratum in: Biochemistry. 2009 Jun 9;48(22):5050. PMID: 19364126

61. Nano-scale imaging and dynamics of amylin-membrane interactions and its implication in type II diabetes mellitus.
Cho WJ, Jena BP, Jeremic AM.
Methods Cell Biol. 2008;90:267-86. doi: 10.1016/S0091-679X(08)00813-3. PMID: 19195555

62. Understanding membrane fusion combining experimental and simulation studies.
Jena BP.
Methods Cell Biol. 2008;90:183-98. doi: 10.1016/S0091-679X(08)00809-1. PMID: 19195551

63. Assembly and disassembly of SNAREs in membrane fusion.
Jena BP.
Methods Cell Biol. 2008;90:157-82. doi: 10.1016/S0091-679X(08)00808-X. PMID: 19195550

64. Intracellular organelle dynamics at nm resolution.
Jena BP.
Methods Cell Biol. 2008;90:19-37. doi: 10.1016/S0091-679X(08)00802-9. PMID: 19195544

65. Extracellular dynamics at nm resolution in live cells.
Jena BP.
Methods Cell Biol. 2008;90:1-18. doi: 10.1016/S0091-679X(08)00801-7. PMID: 19195543

66. Methods in nano cell biology. Preface.
Jena BP.
Methods Cell Biol. 2008;90:xvii-xix. doi: 10.1016/S0091-679X(08)00823-6. PMID: 19195542

67. Nanoscale 3D contour map of protein assembly within the astrocyte porosome complex.
Cho WJ, Ren G, Lee JS, Jeftinija K, Jeftinija S, Jena BP.
Cell Biol Int. 2009 Feb;33(2):224-9. doi: 10.1016/j.cellbi.2008.11.008. PMID: 19084606

68. EM 3D contour maps provide protein assembly at the nanoscale within the neuronal porosome complex.
Cho WJ, Ren G, Jena BP.
J Microsc. 2008 Oct;232(1):106-11. doi: 10.1111/j.1365-2818.2008.02088.x. PMID: 19017207
(EM 3D contour map of the neuronal porosome complex confirming its 15-17 nm size, having a central plug connected to 8 protein densities at the periphery of the structure)

69. Porosome: the universal molecular machinery for cell secretion.
Jena BP.
Mol Cells. 2008 Dec 31;26(6):517-29. Review. PMID: 19011361

70. Ca2+-dimethylphosphate complex formation: providing insight into Ca2+-mediated local dehydration and membrane fusion in cells.
Potoff JJ, Issa Z, Manke CW Jr, Jena BP.
Cell Biol Int. 2008 Apr;32(4):361-6. doi: 10.1016/j.cellbi.2008.03.002. PMID: 18452809
(The study using simulation demonstrated that hydrated Ca2+ is capable of bridging phospholipid head groups, resulting in the expulsion of water from both phospholipid head groups and the calcium ion. The distance between the anionic oxygens in DMP bridged by calcium is 2.92Å, which is in close agreement with the 2.8Å reported in experiments using X-ray diffraction)

71. Porosome in astrocytes.
Lee JS, Cho WJ, Jeftinija K, Jeftinija S, Jena BP.
J Cell Mol Med. 2009 Feb;13(2):365-72. doi: 10.1111/j.1582-4934.2008.00334.x. PMID: 18400049

72. Secretion machinery at the cell plasma membrane.
Jena BP.
Curr Opin Struct Biol. 2007 Aug;17(4):437-43. PMID: 17764925

73. Neuronal fusion pore assembly requires membrane cholesterol.
Cho WJ, Jeremic A, Jin H, Ren G, Jena BP.
Cell Biol Int. 2007 Nov;31(11):1301-8. PMID: 17703958

74. Secretory vesicle swelling by atomic force microscopy.
Cho SJ, Jena BP.
Methods Mol Biol. 2006;319:317-30. PMID: 16719363

75. Porosome: the fusion pore revealed by multiple imaging modalities.
Jena BP.
Methods Mol Biol. 2006;319:295-316. PMID: 16719362

76. Cell secretion machinery: studies using the AFM.
Jena BP.
Ultramicroscopy. 2006 Jun-Jul;106(8-9):663-9. PMID: 16713093

77. Secretory vesicles in live cells are not free-floating but tethered to filamentous structures: a study using photonic force microscopy.
Abu-Hamdah R, Cho WJ, Hörber JK, Jena BP.
Ultramicroscopy. 2006 Jun-Jul;106(8-9):670-3. PMID: 16713090

78. Cholesterol is critical to the integrity of neuronal porosome/fusion pore.
Jeremic A, Jin Cho W, Jena BP.
Ultramicroscopy. 2006 Jun-Jul;106(8-9):674-7. PMID: 16709444

79. Energy-dependent disassembly of self-assembled SNARE complex: observation at nanometer resolution using atomic force microscopy.
Jeremic A, Quinn AS, Cho WJ, Taatjes DJ, Jena BP.
J Am Chem Soc. 2006 Jan 11;128(1):26-7. PMID: 16390104

80. Involvement of water channels in synaptic vesicle swelling.
Jeremic A, Cho WJ, Jena BP.
Exp Biol Med (Maywood). 2005 Oct;230(9):674-80. PMID: 16179736

81. Size of supramolecular SNARE complex: membrane-directed self-assembly.
Cho WJ, Jeremic A, Jena BP.
J Am Chem Soc. 2005 Jul 27;127(29):10156-7. PMID: 16028912
(t-SNAREs and v-SNAREs present in opposing bilayers interact to form a rosette or ring complex. The size of the rosette is directly proportional to the curvature of the SNARE-associated membrane, hence smaller the vesicle higher its curvature, and smaller the size of the t-/v-SNARE rosette)

82. Patch clamped single pancreatic zymogen granules: direct measurements of ion channel activities at the granule membrane.
Kelly ML, Abu-Hamdah R, Jeremic A, Cho SJ, Ilie AE, Jena BP.
Pancreatology. 2005;5(4-5):443-9. PMID: 15985770

83. Direct interaction between SNAP-23 and L-type Ca2+ channel.
Cho WJ, Jeremic A, Jena BP.
J Cell Mol Med. 2005 Apr-Jun;9(2):380-6. PMID: 15963257

84. Cell secretion and membrane fusion.
Jena BP.
Domest Anim Endocrinol. 2005 Jul;29(1):145-65. PMID: 15876511

85. Molecular machinery and mechanism of cell secretion.
Jena BP.
Exp Biol Med (Maywood). 2005 May;230(5):307-19. PMID: 15855297

86. Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane.
Eisenberg ML, Maker AV, Slezak LA, Nathan JD, Sritharan KC, Jena BP, Geibel JP, Andersen DK.
Cell Physiol Biochem. 2005;15(1-4):51-8. PMID: 15665515

87. Vesicle swelling regulates content expulsion during secretion.
Kelly ML, Cho WJ, Jeremic A, Abu-Hamdah R, Jena BP.
Cell Biol Int. 2004;28(10):709-16. PMID: 15516329
(First demonstration that secretory vesicle swelling is a requirement for content release during cell secretion)

88. Structure, isolation, composition and reconstitution of the neuronal fusion pore.
Cho WJ, Jeremic A, Rognlien KT, Zhvania MG, Lazrishvili I, Tamar B, Jena BP.
Cell Biol Int. 2004;28(10):699-708. PMID: 15516328
(Neuronal porosome complex isolated and functionally reconstituted for the first time)

89. Addendum to "Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex" [Cell Biol. Int. 2004(1):7-17].
Abu-Hamdah R, Cho WJ, Cho SJ, Jeremic A, Kelly M, Ilie AE, Jena BP.
Cell Biol Int. 2004;28(5):421. No abstract available. PMID: 15270024

90. Discovery of the Porosome: revealing the molecular mechanism of secretion and membrane fusion in cells.
Jena BP.
J Cell Mol Med. 2004 Jan-Mar;8(1):1-21. PMID: 15090256

91. Calcium drives fusion of SNARE-apposed bilayers.
Jeremic A, Kelly M, Cho JA, Cho SJ, Horber JK, Jena BP.
Cell Biol Int. 2004;28(1):19-31. PMID: 14759765
(This study demonstrates that SNAREs and calcium are the minimal fusion machinery. Furthermore, results from the study suggests that neutralization of the negatively charged phospholipid head groups by Ca2+, results in enhanced membrane–membrane interactions, formation of Ca2+-phosphate bridges between opposing bilayers, freeing bilayers of inter-lamellar water, consequently resulting in lipid mixing and membrane fusion)

92. Membrane fusion: what may transpire at the atomic level.
Jeremic, A., Cho, W-J, Jena, B.P. 
J. Biol. Phys. & Chem. (2004).4:139-142.
(SNAREs overcome repulsive charges and bring opposing bilayers closer to be bridged by calcium. Hydrated calcium ions are too large (6-7 Å) to fit between the space in SNARE-apposed bilayers, and therefore unable to induce membrane fusion. However in the presence of calcium, t-SNARE vesicles interact with v-SNARE vesicles, allowing the formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of water due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion)

93. Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex.
Abu-Hamdah R, Cho WJ, Cho SJ, Jeremic A, Kelly M, Ilie AE, Jena BP.
Cell Biol Int. 2004;28(1):7-17. PMID: 14759764

94. Reconstituted fusion pore.
Jeremic A, Kelly M, Cho SJ, Stromer MH, Jena BP.
Biophys J. 2003 Sep;85(3):2035-43. PMID: 12944316
(Using electron microscopy, first demonstration of secretory vesicle fused to the porosome base, and the structural and functional reconstitution of isolated porosomes into lipid membrane)

95. Fusion pore or porosome: structure and dynamics.
Jena BP.
J Endocrinol. 2003 Feb;176(2):169-74. PMID: 12553865

96. Structure and composition of the fusion pore.
Jena BP, Cho SJ, Jeremic A, Stromer MH, Abu-Hamdah R.
Biophys J. 2003 Feb;84(2 Pt 1):1337-43. PMID: 12547814
(Demonstration that t-SNARE is present at the base of the cup-shaped porosome complex facing the cytosol)

97. New structure involved in transient membrane fusion and exocytosis.
Cho SJ, Wakade A, Pappas GD, Jena BP.
Ann N Y Acad Sci. 2002 Oct;971:254-6. PMID: 12438127

98. Fusion pore in live cells.
Jena BP.
News Physiol Sci. 2002 Dec;17:219-22. PMID: 12433973

99. SNAREs in opposing bilayers interact in a circular array to form conducting pores.
Cho SJ, Kelly M, Rognlien KT, Cho JA, Hörber JK, Jena BP.
Biophys J. 2002 Nov;83(5):2522-7. PMID: 12414686
(t-SNAREs and v-SNARE present in opposing bilayers interact to form a rosette or ring complex establishing a conducting channel in presence of calcium)

100. The atomic force microscope in the study of membrane fusion and exocytosis.
Jena BP, Cho SJ.
Methods Cell Biol. 2002;68:33-50. No abstract available. PMID: 12053737

101. G(alpha)(i3) in pancreatic zymogen granules participates in vesicular fusion.
Sattar AA, Boinpally R, Stromer MH, Jena BP.
J Biochem. 2002 Jun;131(6):815-20. PMID: 12038977 Free Article

102. Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles.
Cho SJ, Sattar AK, Jeong EH, Satchi M, Cho JA, Dash S, Mayes MS, Stromer MH, Jena BP.
Proc Natl Acad Sci USA. 2002 Apr 2;99(7):4720-4. Erratum in: Proc Natl Acad Sci U S A 2002 Oct 1;99(20):13357.
PMID: 11917120
(First demonstration that secretory vesicle volume increase is via the water channel or aquaporin, which is a GTP-mediated event)

103. Structure and dynamics of the fusion pores in live GH-secreting cells revealed using atomic force microscopy.
Cho SJ, Jeftinija K, Glavaski A, Jeftinija S, Jena BP, Anderson LL.
Endocrinology. 2002 Mar;143(3):1144-8. PMID: 11861542

104. Structure and dynamics of the fusion pore in live cells.
Cho SJ, Quinn AS, Stromer MH, Dash S, Cho J, Taatjes DJ, Jena BP.
Cell Biol Int. 2002;26(1):35-42. PMID: 11779219
(Immuno-AFM studies localizing secretory antibody-conjugated gold against secreted protein, demonstrate that the pores present at the cell surface of pancreatic acinar cells are secretory portals)

105. The number of secretory vesicles remains unchanged following exocytosis.
Cho SJ, Cho J, Jena BP.
Cell Biol Int. 2002;26(1):29-33. PMID: 11779218

106. Impaired hepatocyte glucose transport protein (GLUT2) internalization in chronic pancreatitis.
Nathan JD, Zdankiewicz PD, Wang J, Spector SA, Aspelund G, Jena BP, Seymour NE, Geibel JP, Andersen DK.
Pancreas. 2001 Mar;22(2):172-8. PMID: 11249072

107. Insights on membrane fusion.
Jena BP.
Cell Biol Int. 2000;24(11):769-71. PMID: 11067761

108. Continuous detection of extracellular ATP on living cells by using atomic force microscopy.
Schneider SW, Egan ME, Jena BP, Guggino WB, Oberleithner H, Geibel JP.
Proc Natl Acad Sci USA. 1999 Oct 12;96(21):12180-5.PMID: 10518596

109. The native membrane fusion machinery in cells.
Jeong EH, Webster P, Khuong CQ, Abdus Sattar AK, Satchi M, Jena BP.
Cell Biol Int. 1998;22(9-10):657-70.PMID: 10452836

110. Binding contribution between synaptic vesicle membrane and plasma membrane proteins in neurons: an AFM study.
Sritharan KC, Quinn AS, Taatjes DJ, Jena BP.
Cell Biol Int. 1998;22(9-10):649-55. PMID: 10452835

111. ATOMIC FORCE MICROSCOPE: PROVIDING NEW INSIGHTS ON THE STRUCTURE AND FUNCTION OF LIVING CELLS.
Jena BP.
Cell Biol Int. 1997 Nov;21(11):683-684. PMID: 9817808

112. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope.
Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H.
Cell Biol Int. 1997 Nov;21(11):759-68. PMID: 9768474

113. Gi regulation of secretory vesicle swelling examined by atomic force microscopy.
Jena BP, Schneider SW, Geibel JP, Webster P, Oberleithner H, Sritharan KC.
Proc Natl Acad Sci USA. 1997 Nov 25;94(24):13317-22. PMID: 9371843
(GTP-induced live secretory vesicle swelling observed at nanometer resolution in 3D using AFM)

114. Localization of SH-PTP1 to synaptic vesicles: a possible role in neurotransmission.
Jena BP, Webster P, Geibel JP, Van den Pol AN, Sritharan KC.
Cell Biol Int. 1997 Aug;21(8):469-76. PMID: 9451803

115. Exocytotic fusion: total or transient?
Jena BP.
Cell Biol Int. 1997 May;21(5):257-9. PMID: 9243800

116. Surface dynamics in living acinar cells imaged by atomic force microscopy: identification of plasma membrane structures involved in exocytosis.
Schneider SW, Sritharan KC, Geibel JP, Oberleithner H, Jena BP.
Proc Natl Acad Sci USA. 1997 Jan 7;94(1):316-21. PMID: 8990206
(Using AFM, 100-180 nm pores at the apical plasma membrane of live pancreatic acinar cells were observed for the first time. The pores dilated during secretion, and returned to resting size following completion of secretion. Exposure of the cell to the actin depolymerizing fungal toxin cytochalasin, results in collapse of the pore opening and a consequent loss of secretion)

117. Effect of tyrosine kinase inhibition on basal and epidermal growth factor-stimulated human Caco-2 enterocyte sheet migration and proliferation.
Basson MD, Beidler DR, Turowski G, Zarif A, Modlin IM, Jena BP, Madri JA.
J Cell Physiol. 1994 Sep;160(3):491-501. PMID: 8077287

118. Redistribution of a rab3-like GTP-binding protein from secretory granules to the Golgi complex in pancreatic acinar cells during regulated exocytosis.
Jena BP, Gumkowski FD, Konieczko EM, von Mollard GF, Jahn R, Jamieson JD.
J Cell Biol. 1994 Jan;124(1-2):43-53. PMID: 8294505

119. Acidic residues are involved in substrate recognition by two soluble protein tyrosine phosphatases, PTP-5 and rrbPTP-1.
Hippen KL, Jakes S, Richards J, Jena BP, Beck BL, Tabatabai LB, Ingebritsen TS.
Biochemistry. 1993 Nov 23;32(46):12405-12. PMID: 8241130

120. Distinct and specific GAP activities in rat pancreas act on the yeast GTP-binding proteins Ypt1 and Sec4.
Jena BP, Brennwald P, Garrett MD, Novick P, Jamieson JD.
FEBS Lett. 1992 Aug 31;309(1):5-9. PMID: 1511744

121. Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing.
Basson MD, Modlin IM, Flynn SD, Jena BP, Madri JA.
Surgery. 1992 Aug;112(2):299-307; discussion 307-8. PMID: 1353641

122. Protein tyrosine phosphatase stimulates Ca(2+)-dependent amylase secretion from pancreatic acini.
Jena BP, Padfield PJ, Ingebritsen TS, Jamieson JD.
J Biol Chem. 1991 Sep 25;266(27):17744-6. PMID: 1717440

123. Evidence for a rabbit luteal ADP-ribosyltransferase activity which appears to be capable of activating adenylyl cyclase.
Abramowitz J, Jena BP.
Int J Biochem. 1991;23(5-6):549-59. PMID: 1648518

124. Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase.
Abramowitz J, Campbell AR, Jena BP.
Int J Biochem. 1990;22(1):31-7. PMID: 2109707

125. Catecholamine-induced heterologous desensitization of rabbit luteal adenylyl cyclase: loss of luteinizing hormone responsiveness is associated with impaired G-protein function.
Jena BP, Abramowitz J.
Endocrinology. 1989 Apr;124(4):1942-8. PMID: 2538315

126. Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
Jena BP, Abramowitz J.
Endocrinology. 1989 Apr;124(4):1932-41. PMID: 2538314 
 

Reviews, chapters, monographs and editorials (Selected):

1. Jena BP. (2020) Aquaporin regulation: Lessons from secretory vesicles. Aquaporin Regulation Vol. 13 of Vitamins & Hormones Academic Press/Elsevier. Editor: Gerald Litwack 112: 147-162. https://doi.org/10.1016/bs.vh.2019.08.007

2. Jena, B.P. (2020). Preface: Cellular Nanomachines Natures Engineered Marvels. Springer Nature ix-xi, ISBN: 9783030444952

3. Jena, B.P. (2020). Introduction: Cellular Nanomachines Natures Engineered Marvels. Springer Nature xii-xv, ISBN: 9783030444952

4. Jena, B.P. (2020). Porosome: Cells Secretory Nanomachine Natures Engineered Marvels. Springer Nature p1-40, ISBN: 9783030444952

5. Jena, B.P. (2020). Ubiquitine-Proteasome Machinery: Cells Garbage Disposal Natures Engineered Marvels. Springer Nature p41-48, ISBN: 9783030444952

6. Jena, B.P. (2020). Chaperonin: Protein Folding Machinery in Cells Natures Engineered Marvels. Springer Nature p49-56, ISBN: 9783030444952

7. Jena, B.P. (2020). ATP Synthase: Energy Generating Machinery in Cells Natures Engineered Marvels. Springer Nature p57-62, ISBN: 9783030444952

8. Jena, B.P. (2020). Ribosome: Cells Protein Synthetic Machinery Natures Engineered Marvels. Springer Nature p63-70, ISBN: 9783030444952

9. Jena, B.P. (2020). Nuclear Pore: A Bidirectional Transport Machinery Natures Engineered Marvels. Springer Nature p71-78, ISBN: 9783030444952

10. Jena, B.P. (2020). Myosin: Cellular Molecular Motor Natures Engineered Marvels. Springer Nature p79-90, ISBN: 9783030444952

11. Jena, B.P. (2020). Assembly of Cellular Nanomachines Natures Engineered Marvels. Springer Nature p91-104, ISBN: 9783030444952

12. Porosome: Supramolecular Structures at the Synaptosome Membrane Involved in Vesicle Docking, Fusion, and Neurotransmitter Release.
Jena B.P. (2018) Synaptosome Methods and Applications Springer Nature. Editor: Murphy K.; Series Editor: Walz W. Humana Press ISSN: 0893-2336.

13. Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics.
Maheshika Palihawadana-Arachchige, Vaman M. Naik, Prem P. Vaishnava, Bhanu P. Jena, Ratna Naik. (2017) Nanostructured Materials-Fabrication to Application, Chapter 5. INTECH. http://dx.doi.org/10.5772/intechopen.68219.

14. Porosome Enables the Establishment of Fusion Pore at its base and the Consequent Kiss-and-Run Mechanism of Secretion from Cells.
Jena BP. (2017)
Domestic Animal Biology, 2017 August CRC Press. Edited by Scanes, C.G & Hall, R.A. ISBN 9781498747851 - CAT# K27066 425pg (Porosome Cover Illustration)

15. The neuronal porosome complex in health and disease.
Naik AR, Lewis KT, Jena BP. (2016)
Exp Biol Med (Maywood). 2016 Jan;241(2):115-30. doi: 10.1177/1535370215598400. Review. PMID: 26264442

16. 'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion.
Jena BP. (2015)
J Cell Mol Med. 2015 Jul;19(7):1427-40. doi: 10.1111/jcmm.12598. Review. PMID: 26033351

17. Neuronal Porosome-The Secretory Portal at the Nerve Terminal: It's Structure-Function, Composition, and Reconstitution.
Jena BP. (2014)
J Mol Struct. 2014 Sep 5;1073:187-195. PMID: 26412873

18. Porosome in Cystic Fibrosis.
Jena BP. (2014)
Discoveries (Craiova). 2014 Jul-Sep;2(3). pii: e24. PMID: 26413568

19. Atomic force microscopy: High resolution dynamic imaging of cellular and molecular structure in health and disease.
Taatjes DJ, Quinn AS, Rand JH, Jena BP. 
J Cell Physiol. 2013 Oct;228(10):1949-55. doi: 10.1002/jcp.24363.PMID: 23526453

20. Porosome: the secretory NanoMachine in cells.
Jena BP. 
Methods Mol Biol. 2013;931:345-65. doi: 10.1007/978-1-62703-056-4_17. PMID: 23027011

21. Porosome: the secretory portal.
Jena BP. 
Exp Biol Med (Maywood). 2012 Jul;237(7):748-57. doi: 10.1258/ebm.2012.012110. Review. PMID: 22859740

22. Role of SNAREs in membrane fusion.
Jena BP.
Adv Exp Med Biol. 2011;713:13-32. doi: 10.1007/978-94-007-0763-4_3. Review. PMID: 21432012

23. Functional organization of the porosome complex and associated structures facilitating cellular secretion.
Jena BP. 
Physiology (Bethesda). 2009 Dec;24:367-76. doi: 10.1152/physiol.00021.2009. Review. PMID: 19996367 Free Article

24. Membrane fusion: role of SNAREs and calcium.
Jena BP. 
Protein Pept Lett. 2009;16(7):712-7. Review. PMID: 19601899

25. Atomic force microscopy: Unraveling the fundamental principles governing secretion and membrane fusion in cells.
Jena BP.
Ultramicroscopy. 2009 Jul;109(8):1094-104. doi: 10.1016/j.ultramic.2009.03.043. Review. PMID: 19443122

26. Understanding membrane fusion combining experimental and simulation studies.
Jena BP.
Methods Cell Biol. 2008;90:183-98. doi: 10.1016/S0091-679X(08)00809-1. PMID: 19195551

27. Assembly and disassembly of SNAREs in membrane fusion.
Jena BP.
Methods Cell Biol. 2008;90:157-82. doi: 10.1016/S0091-679X(08)00808-X. PMID: 19195550

28. Intracellular organelle dynamics at nm resolution.
Jena BP.
Methods Cell Biol. 2008;90:19-37. doi: 10.1016/S0091-679X(08)00802-9. PMID: 19195544

29. Extracellular dynamics at nm resolution in live cells.
Jena BP.
Methods Cell Biol. 2008;90:1-18. doi: 10.1016/S0091-679X(08)00801-7. PMID: 19195543

30. Methods in nano cell biology. Preface.
Jena BP.
Methods Cell Biol. 2008;90:xvii-xix. doi: 10.1016/S0091-679X(08)00823-6. PMID: 19195542

31. Porosome: the universal molecular machinery for cell secretion.
Jena BP.
Mol Cells. 2008 Dec 31;26(6):517-29. Review. PMID: 19011361

32. Secretion machinery at the cell plasma membrane.
Jena BP.
Curr Opin Struct Biol. 2007 Aug;17(4):437-43. Review. PMID: 17764925

33. Porosome: the fusion pore revealed by multiple imaging modalities.
Jena BP.
Methods Mol Biol. 2006;319:295-316. PMID: 16719362

34. Cell secretion machinery: studies using the AFM.
Jena BP.
Ultramicroscopy. 2006 Jun-Jul;106(8-9):663-9. Review. PMID: 16713093

35. Cell secretion and membrane fusion.
Jena BP.
Domest Anim Endocrinol. 2005 Jul;29(1):145-65. Review. PMID: 15876511

36. Molecular machinery and mechanism of cell secretion.
Jena BP.
Exp Biol Med (Maywood). 2005 May;230(5):307-19. Review. PMID: 15855297

37. Discovery of the Porosome: revealing the molecular mechanism of secretion and membrane fusion in cells.
Jena BP.
J Cell Mol Med. 2004 Jan-Mar;8(1):1-21. Review. PMID: 15090256

38. Fusion pore or porosome: structure and dynamics.
Jena BP.
J Endocrinol. 2003 Feb;176(2):169-74. Review. PMID: 12553865

39. New structure involved in transient membrane fusion and exocytosis.
Cho SJ, Wakade A, Pappas GD, Jena BP.
Ann N Y Acad Sci. 2002 Oct;971:254-6. Review. PMID: 12438127

40. Fusion pore in live cells.
Jena BP.
News Physiol Sci. 2002 Dec;17:219-22. Review. PMID: 12433973

41. The atomic force microscope in the study of membrane fusion and exocytosis.
Jena BP, Cho SJ.
Methods Cell Biol. 2002;68:33-50. PMID: 12053737

42. Insights on membrane fusion.
Jena BP.
Cell Biol Int. 2000;24(11):769-71. PMID: 11067761

43. ATOMIC FORCE MICROSCOPE: PROVIDING NEW INSIGHTS ON THE STRUCTURE AND FUNCTION OF LIVING CELLS.
Jena BP.
Cell Biol Int. 1997 Nov;21(11):683-684. PMID: 9817808

44. Exocytotic fusion: total or transient?
Jena BP.
Cell Biol Int. 1997 May;21(5):257-9. Review. PMID: 9243800